Is Plexus BioCleanse Worth It? A Science-Based Review

Our gut microbiome is the foundation of our overall health. Having a healthy gut means more good bacteria than bad bacteria, and such balance in the gut flora provides many health benefits. 

A healthy gut is vital for your immune system and the hormones, and people who have a healthy gut feel better and have more energy throughout the day. 

That said, poor gut health is often a result of an excess of harmful bacteria, which is why many people use supplements for regulation. One such product is BioCleanse, a detoxifying supplement that might support your body’s cleansing process from harmful toxins. So, how does Plexus BioCleanse work? Read on to find out.

About Plexus BioCleanse

BioCleanse is a dietary supplement intended to reduce unwanted microbes from the gut flora and support your body’s cleansing process. 

It is part of the wide assortment of products from Plexus, a widely-known company providing health and wellness products for their customers. 

The company sells nature-inspired products intended to support the user’s health and help them live happy and healthy lives. 

What Is Plexus BioCleanse Used For?

The colon cleanser is created to possibly help the body clean the gastrointestinal tract by eliminating harmful microbes and substances that often lead to weight gain, constipation, and fatigue. 

It is often used for bowel irregularity and to possibly help in reducing gas, bloating, and gut discomfort. The supplement is made for the detoxification of the body.

Plexus BioCleanse nutrition label

Plexus BioCleanse Ingredients

The Plexus capsules contain the following ingredients:

  • Vitamin C (150mg)
  • Magnesium (380mg)
  • Sodium (50mg) 
  • Citrus bioflavonoids (orange peel powder, lemon peel powder, and quince fruit powder (50mg).

Health Benefits of Plexus BioCleanse Ingredients: Scientific Studies on Effectiveness

Let’s take a closer look at the natural ingredients BioCleanse consists of and the scientific evidence about each of them. 

Vitamin C

Vitamin C is an essential vitamin that is very beneficial for the immune system. It is commonly used to reduce symptoms of colds, but it might also help with iron absorption and protect the cells from the effects of free radicals. 

A study has shown that Vitamin C might improve the gut barrier function, which helps your body absorb the necessary nutrients and protect your body from harmful toxins. 1 This vitamin might help your body balance good and bad bacteria and, by doing so, support gut health.

Studies have shown that this ascorbic acid has known antioxidant and anti-inflammatory properties and might cause several beneficial shifts in bacterial populations, which are associated with gut health. 2 Vitamin C might also boost collagen synthesis, lower blood pressure, and reduce the risk of heart disease


Magnesium is commonly used for boosting energy, and it is known to possibly relieve muscle aches and headaches. It might also be very beneficial for biochemical functions, including the regulation of heart rhythm and brain health. 

Low magnesium levels in the body can lead to constipation and stomach cramps. This mineral plays a huge role in many enzymatic processes in the body, including breaking down food at certain points during digestion.

A study has found that magnesium deficiency might affect the bacteria colons in the gut and induce anxiety-like behavior. 3 Moreover, magnesium is also beneficial for healthy bone formation and cardiovascular health and provides many other health benefits.


BioCleanse contains sodium to maintain the essential balance of the microbiomes and possibly help the body in the cleansing process. 

Sodium might also be beneficial for blood regulation, regulating bodily fluids and is responsible for transmitting electrical impulses within the human body.

Citrus bioflavonoids

Aside from the three main ingredients, it contains citrus bioflavonoids that also offer health benefits. The orange peel might help with digestion and supports immunity and a healthy heart. 

The orange peel also has antioxidant, antibacterial, and antifungal benefits. Additionally, lemon peel is rich in fiber and calcium and might help blood circulation and weight loss. The quince fruit peel might relieve intestinal issues, promote weight loss and regulate blood pressure

Evidence shows that citrus flavanones, as well as their metabolites, might have the potential to contribute to improved gastrointestinal function and health. 4

Plexus BioCleanse vs. Similar Supplements
Credit: Unsplash

Plexus BioCleanse vs. Similar Supplements

Expense and Where to Buy

You can purchase the BioCleanse dietary supplement directly from the brand’s official website. 

The price for a one-time purchase is $49 for a single bottle (180 capsules), but you can also get a subscription and save 10% by maintaining an active monthly subscription. If you purchase on the official website, you also get a 60-day money-back guarantee.

Moreover, Plexus offers multi-level marketing, so you can earn money by promoting and selling products as an ambassador. You can make a purchase by filling out a form, and a Plexus Ambassador will contact you. Then, you have the option to continue as either a retail or a VIP customer, each having its benefits. 

Or you can just buy it on Amazon.

BioCleanse Alternatives

When to Take Plexus BioCleanse

The manufacturers recommend taking two capsules twice a day with 8 ounces of water. You can take the capsules between meals or at night. They can be used with a combination of a reduced-calorie weight loss diet plan for better results. 

When taking such products, consistency is very important. However, the results may vary from one individual to another. 

Is Plexus BioCleanse Safe to Use?

Since BioCleanse is made from natural ingredients, the supplement is considered safe to use. That said, some reviews have stated that this product can cause potential side effects related to the ingredients.

Therefore, before taking the supplement, it is recommended to check whether you are allergic to any of the ingredients. The potential side effects include nausea, upset stomach, weight gain, diarrhea, and headaches.

Who Can Use Plexus BioCleanse?

BioCleanse is for any adult user who wants support for a healthy digestive system. This is also a supplement that can also be used in combination with other products. 

However, pregnant women, nursing mothers, and adults who use other medications should consult a healthcare provider before using such products. BioCleanse is not recommended for users below 18 years old.

Who Can Use Plexus BioCleanse?
Credit: Unsplash

Frequently Asked Questions

What Does the BioCleanse Supplement Do?

BioCleanse is a dietary supplement intended to remove harmful toxins from the body and support a healthy digestive system. The blend of natural ingredients might provide many health benefits for the user, including improved metabolism and energy. 

How Many BioCleanse Supplements Can You Take a Day?

It is recommended to take two capsules twice a day as the manufacturers direct. Exceeding the daily dosage can lead to potential side effects. 

You can take the capsules between meals or at bedtime. The supplement is complementary to the other products provided by Plexus. 

Is BioCleanse Suitable for Users With Dietary Restrictions?

BioCleanse is a vegetarian-friendly supplement that is non-GMO, soy-free, and gluten-free. Hence, it is suitable for users with different dietary restrictions. The supplement is suitable for users who struggle to eat balanced, fiber-rich meals and exercise on a regular basis. 

Related article: Does Plexus Slim work? Science & Ingredients


BioCleanse is a natural supplement provided by the widely-known company Plexus. The capsules contain a blend of natural ingredients intended to promote regularity, support the immune function, aid in cleansing the digestive system, and relieve occasional gas, bloating, and discomfort. 

The product is suitable for users with different dietary restrictions and is free from common food allergens and artificial colors or preservatives. Remember that you should always consult with a professional before using such products!


  1. Traber, M. G., Buettner, G. R., & Bruno, R. S. (2019). The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome. Redox Biology, 21, 101091.
  2. Otten, A. T., Bourgonje, A. R., Peters, V., Alizadeh, B. Z., Dijkstra, G., & Harmsen, H. J. M. (2021). Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut-A Pilot Study. Antioxidants (Basel, Switzerland), 10(8), 1278.
  3. Winther, G., Pyndt Jørgensen, B. M., Elfving, B., Nielsen, D. S., Kihl, P., Lund, S., Sørensen, D. B., & Wegener, G. (2015). Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behavior. Acta neuropsychiatrica, 27(3), 168–176.
  4. Stevens, Y., Rymenant, E. V., Grootaert, C., Camp, J. V., Possemiers, S., Masclee, A., & Jonkers, D. (2019). The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health. Nutrients, 11(7).
About the author

Hans Mast is someone who has always loved science and been passionate about truth. Overhyped claims drive him nuts. He loves to strip away the emotionally-charged sales pitches and hone in on the actual facts. HVG is his attempt to provide that as a service to the world of vitamins, supplements, and herbs.

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