Does Plexus Work for ADHD?

Many of Plexus’ products are associated with success stories related to health conditions, including ADHD. Namely, this neurological condition can make life difficult for the child and their social relationship with the environment.

Many of you might want to know, is it helpful to use Plexus for ADHD? Stay with us as you get all the answers through numerous scientific studies and user testimonials.

Scientific Evidence

Much research has been done recently, suggesting that the gut microbiome is closely related to brain health. Namely, it is believed that improving or maintaining a healthy microbiome is vital to mental health. 

In addition, research has shown that probiotics effectively reduce depression and anxiety. 1 2 Starting from these theses, we will consider the composition of Plexus Slim, Plexus VitalBiome, and Plexus ProBio and their effect on ADHD.

Plexus Slim for ADHD

Plexus Slim for ADHD

Plexus Slim is a supplement that is composed of several active ingredients. Combining these ingredients may help reduce weight and help improve gut health.

Although there is no scientific research related to Plexus Slim and ADHD, I will present the scientific research on Plexus Slim’s ingredients and potential ADHD benefits.

The composition of this product is generally intended to regulate the intestinal microflora and the health of the intestine. However, some ingredients can work to improve the condition of ADHD. Namely, clinical research has been done on caffeine and its role in ADHD. The results showed that caffeine helped cognitive abilities in ADHD patients.3 In another study, caffeinated tea4 affected ADHD patients positively.

Regarding the other ingredients, I have not found relevant clinical data pointing to any testing and their effect on ADHD.

Plexus VitalBiome for ADHD

This product comprises several bacterial strains and aims to improve gut health. Therefore, there is very little data on the effect of the ingredients on people with ADHD. Although Plexus VitalBiome has not been clinically tested in individuals with ADHD, studies have been conducted on some bacterial strains. 

Namely, in studies related to Bifidobacterium bifidum5 6, improvements associated with the intestinal microflora and the condition of ADHD have been observed. However, I found no clinical data on the other strains’ effect on people with ADHD.

Plexus ProBio 5 for ADHD

ProBio 5 is a supplement blend of vitamins, bacterial strains, and enzymes. This combination of ingredients should work towards improving intestinal health.

Regarding ADHD, no relevant evidence exists that ProBio 5 helps reduce such conditions.

However, clinical trials have been conducted on the vitamins contained in this product. Specifically, vitamins B67 and vitamin C8 are successful in alleviating the condition of ADHD. Although there are positive results, further investigations are still needed.


When I researched this topic, I concluded that testimonies related to Plexus for ADHD are rare. Of the ones I’ve found, I didn’t see any association between Plexus products with improvement in ADHD. 

Although there are customers who have seen improvement, you should take such claims with a grain of salt. On the other hand, many satisfied customers claim that Plexus products have helped them improve their overall health.

Based on the above testimonials, it can be seen that there is no strong evidence linking Plexus to improving the condition of ADHD.


In addition to many positive testimonies about Plexus products’ effect, there are also certain controversies related to this brand. Namely, some people associate this company with a pyramid scheme, a cult, or multi-level marketing. In addition, some websites claim that this company targets people with low self-esteem.

“Guys, it is just another MLM (like Herbalife, ItWorks!, Arbonne, etc.) who markets supplements as the key to overall fitness, beauty, and wellness.”

“Especially popular, Plexus Slim (the so-called pink drink), a product for those who think that some powder/shake/magic pill will help them lose weight.”

Is this information relevant and should you believe it? The answer is – it depends. Some customers are satisfied with Plexus products, but they are not approved by the FDA.

Regardless of the purpose for which you will use such products as Plexus, it is best to consult a doctor or professional.

In addition, there is no relevant evidence linking Plexus to ADHD and its actions on this health condition.


So, can you use Plexus for ADHD? After considering all the testimonies, controversies, and clinical trials, several conclusions can be drawn. 

One of the conclusions is that there is no evidence that Plexus products effectively reduce ADHD symptoms. Although some ingredients have positive results, you should not take these results seriously. On the other hand, these products have proven effective for many customers in improving their intestinal microflora.

Although many scientists have found a connection between gut microflora and neurological diseases, further clinical trials are needed to prove this.

Ultimately, such products are not a substitute for regular therapy and medicines prescribed by a doctor. In addition, such products are not approved by the FDA and are not intended to cure or treat a specific medical condition. Therefore, if you have ADHD or any severe disorder, it is best to consult a doctor or a medical professional.


  1. Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota’s effect on mental health: The gut-brain axis. Clin Pract. 2017 Sep 15;7(4):987. doi: 10.4081/cp.2017.987. PMID: 29071061; PMCID: PMC5641835
  2. Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015 Aug;48:258-64. doi: 10.1016/j.bbi.2015.04.003. Epub 2015 Apr 7. PMID: 25862297.
  3. PabloPandolfoabNuno J.MachadobAttilaKöfalvibReinaldo N.TakahashiaRodrigo A.Cunha Bc. Department of Pharmacology, Biological Science Center, Federal University of Santa Catarina, Florianopolis, Brazil. CNC – Center for Neurosciences and Cell Biology of Coimbra, University of Coimbra, Portugal. Faculty of Medicine, University of Coimbra, Portugal
  4. KezhiLiuXuemeiLiangWeihongKuangMental Health Center of West China Hospital, Sichuan University, Chengdu 610041, PR China.
  5. Wang LJ, Yang CY, Kuo HC, Chou WJ, Tsai CS, Lee SY. Effect of Bifidobacterium bifidum on Clinical Characteristics and Gut Microbiota in Attention-Deficit/Hyperactivity Disorder. J Pers Med. 2022 Feb 7;12(2):227. doi: 10.3390/jpm12020227. PMID: 35207715; PMCID: PMC8877879.
  6. Wang LJ, Yang CY, Kuo HC, Chou WJ, Tsai CS, Lee SY. Effect of Bifidobacterium bifidum on Clinical Characteristics and Gut Microbiota in Attention-Deficit/Hyperactivity Disorder. J Pers Med. 2022 Feb 7;12(2):227. doi: 10.3390/jpm12020227. PMID: 35207715; PMCID: PMC8877879.
  7. Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res. 2006 Mar;19(1):46-52. PMID: 16846100.
  8. Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, Chaudhary A, Bhave S, Pandit A. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006 Jan;74(1):17-21. doi: 10.1016/j.plefa.2005.10.001. Epub 2005 Nov 28. PMID: 16314082.
About the author

Hans Mast is someone who has always loved science and been passionate about truth. Overhyped claims drive him nuts. He loves to strip away the emotionally-charged sales pitches and hone in on the actual facts. HVG is his attempt to provide that as a service to the world of vitamins, supplements, and herbs.

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