Plexus ProBio5 vs. other Probiotics: Gut Health Unlocked

The Plexus ProBio 5 is a dietary supplement by the widely-known company Plexus, known for providing health and wellness products for users. Their wide assortment of products is nature-inspired and intended to help the users live a healthy lifestyle. 

Among their supplements is the ProBio 5, formulated to support optimal gut health and help balance intestinal yeast. So, how does Plexus ProBio 5 work? Does it provide effects as advertised? Read on to learn more about the scientific studies regarding this product and find out its results.

About Plexus ProBio 5

The ProBio 5 dietary supplement contains enzymes and probiotics for a healthy digestive environment. Each capsule of ProBio 5 delivers two billion CFU and is free from any artificial colors. The supplement is also gluten-free and suitable for users with different dietary restrictions.

Since bacteria imbalances can lead to many health issues, such as irregular digestion, weight gain, and mood disorders, the supplement is intended to promote healthy gut bacteria levels and a yeast balance in the gut.

What is Plexus ProBio 5 used for?

The daily probiotic supplement may support immune function, maintain a healthy intestinal tract, and help the body to improve the response to natural imbalance. You can also consider taking this product if you are less energized and suffer from constipation or digestive issues.

What Is Plexus Probio 5 Used for

Ingredients of Plexus ProBio 5

The Plexus ProBio 5 dietary supplement contains the following ingredients:

  • Vitamin C (150 milligrams)
  • Vitamin B6 (2.5 milligrams) 
  • Enzyme blend (proteases, cellulase, serrapeptase) (200 milligrams) 
  • Probiotic blend (100 milligrams)
  • Grape seed extract (25 milligrams) 

Health Benefits of Plexus ProBio 5 Ingredients: Scientific Studies on Effectiveness

Vitamin C 

Vitamin C is known as a powerful antioxidant that is very beneficial for the immune system. Based on the US National Library of Medicine, this vitamin can boost metabolism and aid in iron absorption

This water-soluble vitamin is also beneficial for the repair of tissues in parts of your body. Vitamin C can also block damage caused by free radicals. 

Regarding gut health, vitamins such as vitamin C can be very beneficial for maintaining microbial diversity, increasing short-chain fatty acid production, and influencing gastrointestinal health or the microbiome. 1

Vitamin C can also improve the gut barrier function and help the body protect itself from harmful toxins. This vitamin also has anti-inflammatory properties and can perform beneficial shifts in bacterial populations, which is necessary for a healthy gut. 2





Enzyme blend

The ProBio 5 dietary supplement contains an enzymatic blend made of chitosanase, proteases, serrapeptase, and cellulase. 

Such enzymes boost nutrient absorption and help your body retain the necessary vitamins, minerals, and antioxidants. The enzyme blend has strong-inflammatory properties and can prevent blood clot formation

  • Protease – the protease can control blood flow and inflammation, prevent the oxidation of cholesterol and, by doing so, prevent the risk of heart disease. This enzyme is beneficial for healthy digestion. 
  • Chitosanase – this enzyme breaks down chitin, facilitating nutrient absorption and supporting a healthy intestinal environment. 
  • Serrapeptase – the enzyme is known to reduce inflammation and pain, improve skin health, prevent blood clots and dissolve dead tissue in the gut to remove dead candida and other fungi.
  • Cellulase – this enzyme can balance blood sugar levels in the body and work as an energy source for the cells. It can also reduce cholesterol and resist harmful organisms in the gut flora. 

Probiotic blend

Bacillus coagulans 

This spore-forming bacterium is good for one’s immunity and the body’s digestive function. It can neutralize intestinal flora and support a healthy gut which is why it is present in the ProBio 5 capsules. 

This bacteria is also often used as a treatment for plenty of gastrointestinal diseases and can prevent infections associated with Helicobacter pylori. A study has shown that Bacillus coagulans can relieve abdominal pain, diarrhea, and constipation symptoms. 4

Lactobacillus acidophilus

Lactobacillus acidophilus is well-known for its capacity to transform milk’s sugar content into lactic acid. Hence, this probiotic is suitable for lactose intolerant, as it can reduce bloating, gas, and even abdominal pain.

This probiotic can also improve immune response and combat digestive and yeast issues. It can reduce cholesterol, improve symptoms of irritable bowel syndrome and prevent cold and flu symptoms. L. acidophilus may help prevent or reduce diarrhea that is associated with various diseases. 5

Bifidobacterium longum 

The Bifidobacterium longum can enhance nutrient absorption. As a member of the Bifidobacterium probiotic family, it can also help in weight loss. Among its benefits is the ability to lower inflammation and combat harmful pathogens. It can boost digestion rhythms and reduce inflammation. 6

Saccharomyces boulardii 

This probiotic has the ability to enhance immunity and improve digestion. 7 It is recommended for those who suffer from diarrhea, and it normalizes bowel motility. It can be beneficial for the prevention and treatment of several gastrointestinal diseases. 

Lactobacillus plantarum 

This is a probiotic with antimicrobial and antioxidant properties. It is suitable for those who are lactose intolerant and have a sensitive organism. It can positively affect brain health and prevent bloating, gas, cramping, diarrhea, and constipation. 

Studies have shown that this probiotic may help alleviate symptoms of IBS and decrease pain and bloating. 8

Grape seed extract

The grape seed extract can reduce blood pressure and inflammation and support lung, heart, and brain health. The reason why the grape seed extract is on the ingredients list of the Plexus ProBio 5 is that it can restore gut flora and increase antioxidant effectiveness.

Additional ingredients

  • Water 
  • Gelatin
  • Brown rice powder

Plexus ProBio 5 vs. other Probiotics


Compared to other dietary supplements for gut health available online, the Plexus ProBio 5 is on the more expensive side.

You can buy the product by filling out a form, and a Plexus ambassador will contact you. You can also order the supplement directly from Amazon.

Plexus ProBio 5 alternatives

Probiotic Acidophilus – Puritan’s Pride$0.03/dose
60 Billion Probiotic – Physician’s Choice$0.62/dose
900 Billion Probiotic – Nutrition Essentials$0.36/dose
Probiotics, 8 strains, 5 Billion CFU – Solimo$0.20/dose
Plexus ProBio 5$0.82/dose

When to Take Plexus ProBio 5

Taking a capsule of ProBio 5 per day at bedtime is recommended. However, according to Plexus, you can take up to four capsules at bedtime until you achieve the desired results. That said, it is not recommended to exceed this dosage to avoid any unwanted effects. 

Is Plexus ProBio 5 Safe to Use?

Probiotics such as ProBio 5 are generally considered safe to use. However, as with other supplements and medications, you should be very cautious when using such products and contact a healthcare provider for professional advice.

It is also crucial not to exceed the recommended dosage by the manufacturers. Some common side effects that can occur include nausea, dizziness, diarrhea, bloating, and indigestion.

Who Can Use Plexus ProBio 5

The Plexus ProBio 5 is intended for any adult looking for a probiotic supplement. It is suitable for everyone looking for gut health support and healthy digestion. 

Pregnant women, nursing mothers, and adults diagnosed with severe conditions and underlying gastrointestinal issues or symptoms should consult a healthcare professional before using ProBio 5 capsules.

If you are also taking other supplements or medications, it is necessary to contact a healthcare provider before using such products. This is to ensure they are not interfering with each other’s work.

Frequently Asked Questions

What are the main benefits of Plexus ProBio 5?

The majority of the benefits the Plexus ProBio supplement provides are related to intestinal flora. The dietary supplement may also speed up the process of digestion and increase the presence of healthy bacteria in the stomach. 

It is rich in antioxidants and may help maintain PH levels in the gut, improve the natural response to imbalance, and support the immune function.

How many live bacteria are in the ProBio 5 supplement?

According to Plexus, each capsule of ProBio 5 contains two billion probiotic live cells. However, it is important to mention the number was accurate at the time of manufacture. Live bacteria do degrade over time.

Is Plexus ProBio 5 beneficial for weight loss?

The product is made from several ingredients that may benefit gut health, but none are known to promote weight loss. That said, some users reported that taking the product regularly as recommended, together with a healthier meal plan and regular exercise, has significantly helped them in their weight loss process. However, Plexus Slim and Plexus Lean are the primary Plexus Worldwide products intended to assist with weight loss.


The Plexus ProBio 5 is a probiotic supplement formulated using ingredients that can support a healthy digestive system. While the product costs more than other alternative supplements, it also differentiates from them in its formula. 

An important thing to mention is that the results may vary from user to user, which can also be seen in the reviews of various users. Remember to contact a healthcare professional before taking it and use it as recommended to avoid unwanted effects.


  1. Pham, V. T., Dold, S., Rehman, A., Bird, J. K., & Steinert, R. E. (2021). Vitamins, the gut microbiome and gastrointestinal health in humans. Nutrition Research, 95, 35-53.
  2. Otten,%20A.%20T.,%20Bourgonje,%20A.%20R.,%20Peters,%20V.,%20Alizadeh,%20B.%20Z.,%20Dijkstra,%20G.,%20&%20Harmsen,%20H.%20J.%20M.%20(2021).%20Vitamin%20C%20Supplementation%20in%20Healthy%20Individuals%20Leads%20to%20Shifts%20of%20Bacterial%20Populations%20in%20the%20Gut-A%20Pilot%20Study.%20Antioxidants%20(Basel,%20Switzerland),%2010(8),%201278.%20
  3. %20Hossain, K. S., Amarasena, S., & Mayengbam, S. (2022). B Vitamins and Their Roles in Gut Health. Microorganisms, 10(6).
  4. Rogha, M., Esfahani, M. Z., & Zargarzadeh, A. H. (2014). The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterology and Hepatology From Bed to Bench, 7(3), 156-163
  5. Sazawal, S., Hiremath, G., Dhingra, U., Malik, P., Deb, S., & Black, R. E. (2006). Efficacy of probiotics in prevention of acute diarrhea: a meta-analysis of masked, randomized, placebo-controlled trials. The Lancet. Infectious diseases, 6(6), 374–382.
  6. Yao, S., Zhao, Z., Wang, W., & Liu, X. (2021). Bifidobacterium Longum: Protection against Inflammatory Bowel Disease. Journal of Immunology Research, 2021.
  7. Kelesidis, T., & Pothoulakis, C. (2012). Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therapeutic Advances in Gastroenterology, 5(2), 111-125.
  8. Ducrotté, P., Sawant, P., & Jayanthi, V. (2012). Clinical trial: Lactobacillus Plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World journal of gastroenterology, 18(30), 4012–4018.
About the author

Hans Mast is someone who has always loved science and been passionate about truth. Overhyped claims drive him nuts. He loves to strip away the emotionally-charged sales pitches and hone in on the actual facts. HVG is his attempt to provide that as a service to the world of vitamins, supplements, and herbs.

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